Nanoparticles for Targeted Delivery of Active Agen

专利名称：Nanoparticles for Targeted Delivery of

Active Agents to the Lung

发明人：Jürgen Borlak,Shimon Benita,Nir

Debotton,Nour Karra,Oshrat Harush-Frenkel

申请号：US13687288申请日：20121128

公开号：US20130136688A1公开日：20130530

专利附图：

摘要：The present invention concerns a delivery system administered to the lungpreferably by inhalation comprising a polymer-based nanoparticle; and a linker

comprising a first portion non-covalently anchored to said nanoparticle, wherein at leastpart of said first portion comprises a hydrophobic/lipophilic segment embedded in saidnanoparticle; and a second portion comprising a coupling group, preferably a maleimidecompound, exposed at the outer surface of said nanoparticle. In accordance with oneembodiment, the delivery system comprises one or more targeting agents, eachcovalently bound to said coupling group, preferably maleimide compound, and isadministered as an aerosol in the therapy or diagnosis of lung cancer or bronchialdysplasia. In accordance with yet another embodiment, the delivery system comprises adrug and/or a radiopharmaceutical and/or a contrasting agent. A specific example for alinker in accordance with the invention is octadecyl-4-(maleimideomethyl)cyclohexane-carboxylic amide (OMCCA).

申请人：Jürgen Borlak,Shimon Benita,Nir Debotton,Nour Karra,Oshrat Harush-Frenkel

地址：Lehrte/OT Immensen DE,Tel Aviv IL,Tel Aviv IL,Tel Aviv IL,Modiin IL

国籍：DE,IL,IL,IL,IL

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