Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :A-443654552325-16-3HY-10425397.47C24H23N5O>98%Solubility:DMSOMechanisms: Pathways:PI3K/Akt/mTOR ; Target:Akt gyBiological Activity:A-443654 (A 443654) is useful for anti-cancer.References:[1]. Fala, Federica; Blalock, William L.; Tazzari, Pier Luigi; Cappellini, Alessandra; Chiarini,Francesca; Martinelli, Giovanni; Tafuri, Agostino; McCubrey, James A.; Cocco, Lucio; Martelli,Alberto M. Proapoptotic activity and chemosensitizing effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acutey)[(yy)pyy]ypp()Lymphoblastic Leukemia. Molecular Pharmacology (2008), 74(3), 884-895. [2]. Han EK, Leverson JD, McGonigal T, Shah OJ, Woods KW, Hunter T, Giranda VL, Luo Y.Aktinhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1inhibition.Oncogene. 2007 Aug 16;26(38):5655-61. Epub 2007 Mar 5. [3]. Liu X, Shi Y, Woods KW, Hessler P, Kroeger P, Wilsbacher J, Wang J, Wang JY, Li C, Li Q,Rosenberg SH, Giranda VL, Luo Y.Akt inhibitor a-443654 interferes with...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com
