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实验--甲硝唑药动学参数的测定

来源:知库网
t0.250.512358

1.081.061.041.0210.980.960.940.920.90.880A0.6820.780.760.7480.5840.2880.33C

11.9662113.6463213.3034413.0977110.28615.2114725.93152logCCr1.07795711.28521.1350167.86171.1239641.1171951.0122510.716960.773166

logCr1.05250.8955

logCr= -0.628t + 1.20950.20.40.6a'=1.2095b'=-0.628

C0'=log-1a'=16.1994(mg/L)

Ka=b'*-2.303=1.4463(h-1)T1/2Ka=0.693/Ka=0.4792(h)

1.210.8取t=2,3,5时的logC值

0.60.40.20logC= -0.1354t + 1.4003R2= 0.9940246-1

a=1.4003b=-0.1354

C0=loga=25.14(mg/L)

Ke=-2.303*b=0.3118(h-1)T1/2Ke=0.693/Ke=2.2229(h)

Tmax=[ln(Ka/Ke)]/(Ka-Ke)=1.3525(h)AUC=C0'/Ke+C0/Ka=69.3367(h*mg*L-1)Cmax=C0*e-Ke·Tmax-C0'*e-Ka·Tmax=14.1993(mg/L)

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