专利名称：Improved synthesis of sulfurized
oligonucleotides
发明人：DOUGLAS L. COLE,VASULINGA T.
RAVIKUMAR,ZACHARIA S. CHERUVALLATH
申请号：AU2776801申请日：20010110公开号：AU2776801A公开日：20010724
摘要：Methods for the formation of sulfurized oligonucleotides are provided. Themethods allow for the formation of phosphorothioate linkages in the oligonucleotides orderivatives, without the need for complex solvent mixtures and repeated washing orsolvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotidescan be sulfurized according to the methods of the invention with higher yields than havebeen previously reported.
申请人：ISIS PHARMACEUTICALS, INC.
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